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It was first described by Krompecher in 1918 as congenital Melanocarcinoma thereafter different names were used till the term MNTI was coined by Borello and Gorlin after confirmation of the nature & neuroectodermal origin of the tumor by immunocytochemistry & electromicroscopic study [2, 4, 6]

Our clinical studies indicate the best results after 6-8 weeks of continuous use

The 7% body weight reduction observed in mouse models may not translate proportionally to human weight loss it could be more, less, or require entirely different dosing and duration

Neurochem Res 47(7):18531864 Cho JH et al (2021) Anti-inflammatory effects of melatonin: a systematic review and meta-analysis of clinical trials